Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media

Registro completo

Título

Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media

Autor(es)

Matesanz, Ana I.; Jimenez Faraco, Eva; Ruiz, María Carolina; Balsa, Lucía Mariana; Navarro Ranninger, Carmen; León, Ignacio Esteban; Quiroga, Adoración G.

Afiliación(es) del/de los autor(es)

Balsa, Lucía Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica; Argentina.
León, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino";Argentina
León, Ignacio Esteban. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Ruiz, María Carolina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica; Argentina

Resumen

Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.
Facultad de Ciencias Exactas
Centro de Química Inorgánica

Año de publicación

2017

Idioma

inglés

Formato (Tipo MIME)

application/octet-stream
Data were collected on a Bruker Kappa Apex II diffractometer. The software package SHELXTL was used for space group determination, structure solution, and refinement. The structure was solved by direct methods, completed with difference Fourier syntheses, and refined with anisotropic displacement parameters.

Clasificación temática de acuerdo a la FORD

Ciencias químicas

Materia

Ciencias Exactas; Química; mononuclear structures; biological interactions; Pd(II) complex; Pt(II) complex;

Condiciones de uso

Disponible en acceso abierto bajo licencia Creative Commons http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0)

Repositorio digital

SEDICI (UNLP) - Universidad Nacional de La Plata

Publicación referenciada

http://hdl.handle.net/hdl/10915/109054