{"id":"SEDICI_0f89f19a81f60dcd5d37687e1a90639b","dc:title":"Data from: Mononuclear Pd(II) and Pt(II) complexes with an \u03b1-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus<\/i> proven models from biological media","dc:creator":"Quiroga, Adoraci\u00f3n G.","dc:date":"2024","dc:description":["Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.","Facultad de Ciencias Exactas","Centro de Qu\u00edmica Inorg\u00e1nica"],"dc:format":["application\/octet-stream","Data were collected on a Bruker Kappa Apex II diffractometer. The software package SHELXTL was used for space group determination, structure solution, and refinement. The structure was solved by direct methods, completed with difference Fourier syntheses, and refined with anisotropic displacement parameters."],"dc:language":["eng"],"dc:type":"dataset","dc:subject":["Ciencias Exactas","Qu\u00edmica","mononuclear structures","biological interactions","Pd(II) complex","Pt(II) complex"],"dc:rights":["info:eu-repo\/semantics\/openAccess","http:\/\/creativecommons.org\/licenses\/by\/4.0\/","Creative Commons Attribution 4.0 International (CC BY 4.0)"],"dc:relation":["info:eu-repo\/semantics\/reference\/hdl\/10915\/109054"],"dc:identifier":"https:\/\/repositoriosdigitales.mincyt.gob.ar\/vufind\/Record\/SEDICI_0f89f19a81f60dcd5d37687e1a90639b"}