{"id":"RDUUNC_8410a4027ad8d632655a9280c343c231","dc:title":"Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.0164 mM","dc:creator":"Aon, Miguel","dc:date":"2018","dc:description":["Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equations. To allow transient states to vanish, the system was computed during a time lapse of 2 e8 ms. All studies were performed using the parameter setting optimized in our previous work (Kembro et al. 2013. Biophys J 104(2):332-343; Kembro et al., 2014. Front Physiol 5:257), with ADPm = 0.01mM, i.e. consistent with energized mitochondria under state 4 respiration. The two .txt file represents the time reference and the time series of variables output of the model, in order from left to right column: 1) Mitochondrial Ca+;2) Mitochondrial ADP; 3) Membrane potential; 4)Mitocondrial NADH; 5) Mitochondrial H+; 6) Mitochondrial Phosfate, Pi; 7) Isocitrate; 8) a-ketoglutarate; 9) Succinyl CoA; 10) Succinate; 11) Fumarate; 12) Malate; 13) Oxaloacetate; 14) NADPH; 15) Mitochondrial superoxide; 16) Extramitochondrial superoxide; 17) Mitochondrial hydrogen peroxide; 18) Extramitochondrial hydrogen peroxide; 19) Mitochondrial GSH; 20) Extramitochondrial GSH; 21)Mitochondrial GSSG; 22) Mitochondrial TrxSH2; 23) ExtramitochondrialTrxSH; 24)Mitochondrial PSSGm; 25) Extramitochondrial PSSG."],"dc:format":["application\/zip"],"dc:language":["eng"],"dc:type":"dataset","dc:subject":["Animal Physiology - Biophysics","Animal Physiology - Systems","Biophysics","Mitochondria","Bioenergetics model","Oxidative stress effects","Oxidative stress enzymes"],"dc:rights":["info:eu-repo\/semantics\/openAccess"],"dc:relation":["info:eu-repo\/semantics\/altIdentifier\/https:\/doi\/10.6084\/m9.figshare.6025748.v1","https:\/\/rdu.unc.edu.ar\/handle\/11086\/17029"],"dc:identifier":"https:\/\/repositoriosdigitales.mincyt.gob.ar\/vufind\/Record\/RDUUNC_8410a4027ad8d632655a9280c343c231"}