DACyTAr - Datos Primarios en Acceso Abierto de la Ciencia y la Tecnología Argentina
Base de datos de polimorfismo In/Del de Cromosoma X en población Argentina
Registro completo
- Título
- Base de datos de polimorfismo In/Del de Cromosoma X en población Argentina
- Autor(es)
- Caputo, Mariela; Corach, Daniel
- Afiliación(es) del/de los autor(es)
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Caputo, Mariela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
- Resumen
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Aiming to determine their ancestry diagnostic potential, we selected two sets of nuclear deletion/insertion polymorphisms (DIPs), including 30 located on autosomal chromosomes and 33 on the X chromosome. We analysed over 200 unrelated Argentinean individuals living in urban areas of Argentina. As in most American countries, the extant Argentinean population is the result of tricontinental genetic admixture. The peopling process within the continent was characterised by mating bias involving Native American and enslaved African females and European males. Differential results were detected between autosomal DIPs and X-DIPs. The former showed that the European component was the largest (77.8%), followed by the Native American (17.9%) and African (4.2%) components, in good agreement with the previously published results. In contrast, X-DIPs showed that the European genetic contribution was also predominant but much smaller (52.9%) and considerably larger Native American and African contributions (39.6% and 7.5%, respectively). Genetic analysis revealed continental genetic contributions whose associated phenotypic traits have been mostly lost. The observed differences between the estimated continental genetic contribution proportions based on autosomal DIPs and X-DIPs reflect the effects of autosome and X-chromosome transmission behaviour and their different recombination patterns. This work shows the ability of the tested DIP panels to infer ancestry and confirm mating bias. To the best of our knowledge, this is the first study focusing on ancestry-informative autosomal DIP and X-DIP comparisons performed in a sample representing the entire Argentinean population.
- Año de publicación
- Idioma
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inglés
- Formato (Tipo MIME)
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application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
- Clasificación temática de acuerdo a la FORD
- Ciencias biológicas
- Condiciones de uso
- Disponible en acceso abierto bajo licencia Creative Commons https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Citación
Caputo, Mariela Corach, Daniel (): Base de datos de polimorfismo In/Del de Cromosoma X en población Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas, http://hdl.handle.net/11336/200181.