{"id":"CONICETDig_5e3e5315f6427894825a1611341da468","dc:title":"Alteraciones en la memoria de cr\u00edas de ratas expuestas a Fl\u00faor durante la gestaci\u00f3n y la lactancia","dc:creator":"Minetti, Silvia Alejandra","dc:date":"2024","dc:description":["Daily exposure to fluoride (F) depends mainly on the intake of this element with drinking water. When administered during gestation and lactation, F has been associated with cognitive deficits in the offspring. However, the mechanisms underlying the neurotoxicity of F remain obscure. In the current study, we investigated the effects of oral exposure to low levels of F during the gestational and lactation periods, on the memory of adult female rat offspring. We also considered a possible underlying neurotoxic mechanism. Our results showed that this exposure reduced step-down latency in the inhibitory avoidance task, and decreased both mRNA expression of the \u03b17 nicotinic receptor (nAChR) and catalase activity in hippocampus. Our data indicates that low F concentrations administrated during gestation and lactation decrease the memory of 90-day-old female offspring. This suggests that the mechanism might be connected with an \u03b17 nAChR deficit in the hippocampus, induced by oxidative stress."],"dc:format":["application\/postscript","application\/vnd.openxmlformats-officedocument.wordprocessingml.document"],"dc:language":["eng"],"dc:type":"dataset","dc:rights":["info:eu-repo\/semantics\/restrictedAccess","Datos sujetos al derecho de propiedad intelectual"],"dc:relation":["info:eu-repo\/grantAgreement\/Universidad Nacional del Sur\/PGI 24\/B223","info:eu-repo\/grantAgreement\/Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas\/PGI 24\/B223","info:eu-repo\/grantAgreement\/\/PGI 24\/B223"],"dc:identifier":"https:\/\/repositoriosdigitales.mincyt.gob.ar\/vufind\/Record\/CONICETDig_5e3e5315f6427894825a1611341da468"}