{"id":"CONICETDig_4c967f035c0e0b3253ca151431516101","dc:title":"Efectos del hipotiroidismo sobre el tejido adiposo abdominal","dc:creator":"Caron, Ruben Walter","dc:date":"2024","dc:description":["To characterize the influence of hypothyroidism on the endocrine activity of mesenteric and omental adipose tissue (MOAT) and the peripheral regulation of energy balance (EB) in rats, we analyzed food intake (FI); basal metabolic rate (BMR); locomotor activity; body weight (BW); serum hormone concentrations and the expression of their receptors in MOAT. We evaluated the morphology and differentiation of adipocytes. Hypothyroidism decreased FI, BMR and BW. The percentage of visceral white adipose tissue (WAT) depots and the morphology of adipocytes were similar to euthyroid rats. Serum leptin and adiponectin expression in MOAT were altered by hypothyroidism. The expression of Perilipin 1, HSL, UCP1 and PRDM16 was significantly lower in MOAT of hypothyroid animals. Hypothyroidism in rats leads to a compensated EB by inducing a white adipocyte dys-function and a decrease in BW, BMR, FI and adipokine secretions without changing the percentage of WAT depots and the morphology of the MOAT."],"dc:format":["application\/vnd.openxmlformats-officedocument.spreadsheetml.sheet","image\/jpeg","application\/octet-stream","application\/vnd.ms-excel"],"dc:language":["eng"],"dc:type":"dataset","dc:rights":["info:eu-repo\/semantics\/restrictedAccess","Protecci\u00f3n de datos personales (Ley 25.326)"],"dc:relation":["info:eu-repo\/grantAgreement\/Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas. Centro Cient\u00edfico Tecnol\u00f3gico Conicet - Mendoza\/","info:eu-repo\/grantAgreement\/Ministerio de Salud. Instituto Nacional del C\u00e1ncer\/","info:eu-repo\/grantAgreement\/\/"],"dc:identifier":"https:\/\/repositoriosdigitales.mincyt.gob.ar\/vufind\/Record\/CONICETDig_4c967f035c0e0b3253ca151431516101"}