{"id":"CONICETDig_3e64189453073919e1cf851473c77e1c","dc:title":"Evaluaci\u00f3n de la memoria de corta y larga duraci\u00f3n y estado neuroqu\u00edmico del cerebro en ratas expuestas a bajas concentraciones de Ars\u00e9nico durante el desarrollo","dc:creator":"Gumilar, Fernanda Andrea","dc:date":"2024","dc:description":["Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of the exposure to low arsenite sodium levels through drinking water during pregnancy and lactation on short- and long-term memory. We also considered a possible underlying neurotoxic mechanism. Pregnant rats were exposed during pregnancy and lactation to environmentally relevant iAs concentrations (0.05 and 0.10 mg\/L). In 90-day-old female offspring, short-term memory (STM) and longterm memory (LTM) were evaluated using a step-down inhibitory avoidance task. In addition, we evaluated the a7 nicotinic receptor (a7-nAChR) expression, the transaminases and the oxidative stress levels in hippocampus. The results showed that the exposure to 0.10 mg\/L iAs in this critical period produced a significant impairment in the LTM retention. This behavioral alteration might be associated with several events that occur in the hippocampus: decrease in a7-nAChR expression, an increase of glutamate levels that may produce excitotoxicity, and a decrease in the antioxidant enzyme catalase (CAT) activity."],"dc:format":["application\/vnd.openxmlformats-officedocument.spreadsheetml.sheet","application\/vnd.openxmlformats-officedocument.wordprocessingml.document","application\/octet-stream"],"dc:language":["eng"],"dc:type":"dataset","dc:rights":["info:eu-repo\/semantics\/restrictedAccess","Datos sujetos al derecho de propiedad intelectual"],"dc:relation":["info:eu-repo\/grantAgreement\/Ministerio de Ciencia. Tecnolog\u00eda e Innovaci\u00f3n Productiva. Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica\/PICT2013-2012","info:eu-repo\/grantAgreement\/Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas\/PICT2013-2012","info:eu-repo\/grantAgreement\/Universidad Nacional del Sur\/PICT2013-2012","info:eu-repo\/grantAgreement\/\/PICT2013-2012"],"dc:identifier":"https:\/\/repositoriosdigitales.mincyt.gob.ar\/vufind\/Record\/CONICETDig_3e64189453073919e1cf851473c77e1c"}